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Saturday, May 16, 2020 | History

4 edition of Pathophysiology of lipid peroxides and related free radicals found in the catalog.

Pathophysiology of lipid peroxides and related free radicals

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Published by Japan Scientific Societies Press, Karger in Tokyo, Basel, New York .
Written in English

    Subjects:
  • Lipids -- Peroxidation -- Pathophysiology.,
  • Free radicals (Chemistry) -- Pathophysiology.

  • Edition Notes

    Includes bibliographical references and index.

    Statementedited by Kunio Yagi.
    ContributionsYagi, Kunio.
    Classifications
    LC ClassificationsRB170 .P38 1998
    The Physical Object
    Paginationix, 182 p. :
    Number of Pages182
    ID Numbers
    Open LibraryOL436325M
    ISBN 103805565909
    LC Control Number98145628

    1. Author(s): Yagi,Kunio Title(s): Pathophysiology of lipid peroxides and related free radicals/ edited by Kunio Yagi. Country of Publication: Japan Publisher: Tokyo: Basel ; New York: Japan Scientific Societies Press ; Karger, c Strictly speaking, the free radical theory is only concerned with free radicals such as superoxide (O 2−), but it has since been expanded to encompass oxidative damage from other reactive oxygen species such as hydrogen peroxide (H 2 O 2), or peroxynitrite (OONO −).

    "Proceedings of the 5th International Congress on Oxygen Radicals: active oxygen, lipid, peroxides and antioxidants, Kyoto, Novembe, " Description: xx, pages: illustrations ; 25 cm: Contents: Active oxygens and free radicals: Generation, reaction and detection (57 papers). Lipid peroxides: Generation, reaction and detection ( Lipid Peroxides and Related Radicals in Clinical Medicine / K. Yagi --Reactive Oxygen Species in Normal Physiology, Cell Injury and Phagocytosis / M. Treinen Moslen --Free Radical Mechanisms for Chromosomal Instability in Bloom's Syndrome / T.M. Nicotera --The Analysis of Free Radicals, Lipid Peroxides, Antioxidant Enzymes and Compounds Related.

    Abstract. Oxygen free radicals (OFRs) are known to produce a decrease in cardiac function and contractility. The decrease in cardiac contractility and function in chronic volume overload heart failure might be due to an increased level of OFRs and/or decrease in the antioxidant : Jawahar Kalra. Free radicals resulting in lipid peroxidation propagation phase Lipid peroxidation is a complex process consisting of three major phases: initiation, propagation and end of the reaction. The initiation phase is slow due to the need of accumulation of a sufficient quantity of ROS, followed by the activation process of oxygen which is the Cited by: 7.


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Pathophysiology of lipid peroxides and related free radicals Download PDF EPUB FB2

The pathophysiology of lipid peroxides and related free radicals is now recognized to be one of the most important issues in the pathogenesis of many diseases. This volume covers diverse topics such as retinal pathology, digestive diseases, antioxidant defence and cancer chemotherapy, as well as more abstract topics related to lipid peroxides and free radicals.

Lipoxygenases - transformations of their hydroperoxy products; detection of oxidized phosphatidylcholines in human athersclerotic lesions and in plasma LDL fractions; interaction of superoxide, nitric oxide, and peroxynitite under various pathological conditions; involvements of superoxide and nitric oxide on asthma-like features induced by diesel exhaust particles in mice; dose dependent mechanisms of lipid hydroperoxide induced retinal pathology.

In the eye, lipid peroxidation has been reported to play an important role in degenerative ocular diseases (age-related macular degeneration, cataract, glaucoma, diabetic retinopathy). Indeed, ocular tissues are prone to damage from reactive oxygen species due to stress from constant exposure of the eye to sunlight, Cited by: One is a large Ca 2+ influx and the other is an accumulation of free radicals and lipid peroxides as a result of neural membrane phospholipid degradation.

It is suggested that calcium and free radicals act in concert to induce neuronal injury in acute trauma (ischemia and spinal cord injury) and in neurodegenerative by: The Analysis of Free Radicals, Lipid Peroxides, Antioxidant Pathophysiology of lipid peroxides and related free radicals book and Compounds Related to Oxidative Stress as Applied to the Clinical Chemistry Laboratory p.

43 Free Radicals and the Pathogenesis of Neuronal Death: Cooperative Role of Excitatory Amino Acids p. 59 Free Radicals and Ocular Disease p.

73 Active Oxygen Mechanisms of UV. For example, normal subjects will have less than 4 nmol/ml of serum lipid peroxides, while a person with diabetes generally has equal or greater than and a diabetic person with vascular complications often exceeds nmol/ml.

Serum TBA is a clinically important measure that relates to aging, gender and estrogen as an antioxidant, in the prognosis for vascular disorders, and in pathological conditions. Abstract. Inwhen the author organized an international symposium on “Lipid Peroxides in Biology and Medicine” 1, he was convinced that the research on the significance of lipid peroxides and their related free radicals in medicine had gotten off to a good fter, many valuable results on this topic have been accumulated, and the problem has become of practical importance Cited by: Lipid peroxidation is initiated by free radicals, generated predominantly within the mitochondria, which scavenge electrons from membrane lipids, with omega-6 polyunsaturated fatty acids being.

Pathophysiology of mitochondrial lipid oxidation: Role of 4-hydroxynonenal (4-HNE) and other bioactive lipids in mitochondria. Free Radical Biology and Medicine, DOI: /dbiomedCited by:   Lipid peroxidation is a process in which free radical species such as oxyl radicals, peroxyl radicals, and hydroxyl radicals remove electrons from lipids and subsequently produce reactive intermediates that can undergo further by: 2.

By definition, radicals possess an unpaired electron, which makes them highly reactive and thereby able to damage all macromolecules, including lipids, proteins and nucleic acids. One of the best known toxic effects of oxygen radicals is damage to cellular membranes (plasma, mitochondrial and endomembrane systems), which is initiated by a process known as lipid peroxidation.

Oxygen-derived free radicals such as hydroxyl and hydroperoxyl species have been demonstrated to oxidize membrane lipid components, mainly phospholipids, leading to lipid peroxidation.

Membrane phospholipids containing polyunsaturated fatty acids are predominantly susceptible to by: 9. Esterbauer H () Lipid peroxidation products: formation, chemical properties and biological activities. In: Poli G, Cheeseman KH, Dianzini MU, Stater TF (eds) Free radicals in liver injury. IRL Press, Oxford, pp 29– Google ScholarCited by: 3.

Lipid peroxides are an important class of reactive oxygen species. • Lipid peroxides can be synthesized in many contexts and are mediators of disease and death. • Lipid peroxidation is a hallmark of ferroptosis, and emerging form of regulated cell death. • Alzheimer’s disease is a neurodegenerative disease characatarized by lipid Cited by: 1.

Introduction. Free radicals are generated naturally and are believed to be critically involved in several disease states, including ischemic disease, drug-associated toxicity, and complications resulting from transplantation.In particular, oxygen-derived free radicals induced by ischemia-reperfusion have been studied as a contributing cause of cellular injury in the liver, lung Cited by: An International Syaposiua on Free Radicals in Diagnostic Medicine was co-sponsored by the state University of New York at Buffalo, Roswell Park Cancer Institute, and the Upstate NY Section of the American Association of Clinical Chemistry.

The theme was "A Systems Approach To Laboratory Lipid Peroxides and Related Radicals in Clinical. As noted previously, free fatty acids are released throughout ischemia. On exposure to oxygen radical species, these free fatty acids are vulnerable to lipid peroxidation.

Lipid membranes are a natural target of free radicals, especially in the brain, because they are abundant, and their polyunsaturated nature makes them easy to oxidize.

Furthermore, free radicals catalyze lipid peroxidation, a chain reaction mediated by polymorphonuclear leukocytes (PMN), and a phenomenon extremely toxic to cellular membranes. Our experiments will directly measure the production of free radicals during shock and resuscitation in organ systems that have been clinically shown to be the most Cited by: 1.

Introduction Involvement of nitric oxide in pathophysiological processes. Following its discovery as an endothelial-derived relaxing factor (EDRF), nitric oxide (• NO) has been found to play a critical role in numerous physiological processes, as well as in the pathophysiology of many human importance of • NO as a biological mediator is highlighted by the recent Cited by: Oxidative Stress and Lipid Peroxidation – A Lipid Metabolism Dysfunction 35 Highly reactive aldehydes are one of the major causative factors in oxidative related cardiovascular pathology and ageing.

This book summarizes the contributions of the Free Radical School 'Free Radicals and Diseases: Gene Expression, Cellular Metabolism and Pathophysiology' held in Spetses from Sept. 21 until Oct. 1, A Special Lecture on the relevance of free radical analysis to clinical medicine was presented by Professor Kunio Yagi of Japan.

The Yagi procedure to measure thiobarbituric acid (TBA) reaction reflects the amount of reactive substances, lipid peroxides and aldehydes, in the sample.The free radical peroxidation of lipids is an important factor in local injury to cell mem-branes and impairment of the activity of enzymes and receptors bound to the mem-brane, and the lipid peroxide thus produced can affect even remote organs.

Among the agents that protect the body from lipid peroxidation, vitamin E is consid.